11-Desoxycortisol (LDCOR) | | | |
EPIC Test Name
11-DESOXYCORTISOLEPIC Code
LAB975Reference Lab
This test is performed by a partner lab as indicated below.
Specimen Requirements
Serum |
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Minimum Volume: | 0.5mL/0.2mL |
Transport: | Frozen |
Container: | Gold top gel/Red top |
Rejection Causes: | Recently administered isotopes |
Special Instructions
No isotopes administered 24 hours prior to venipuncture.Clinical Indications
Evaluate hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve.Additional Information
11-Deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol. The conversion of 11-deoxycortisol to cortisol is inhibited by metyrapone, which acts on 11-β-hydroxylase. The metyrapone test (see the online Endocrine Appendix: ACTH Stimulation) serves as a reliable and sensitive indicator of pituitary ACTH secretory reserve. The 11-deoxycortisol levels normally increase to 100 times the control value following metyrapone administration. Reduced response occurs in patients with hypoadrenalism or with hypopituitarism and in some patients with diseases of the hypothalamus. Patients with myxedema, some pregnant patients, and those on oral contraceptives respond poorly.Common Synonyms
Compound S for Metyrapone Test, RL 500550References
Sindler BH, Griffing GT, Melby JC, et al. The superiority of the metyrapone test versus the high-dose dexamethasone test in the differential diagnosis of Cushing's syndrome. Am J Med. 1983 Apr; 74(4):657-662. PubMed 6837591
Spark RF. Simplified assessment of pituitary-adrenal reserve: Measurement of serum 11-deoxycortisol after metyrapone. Ann Intern Med. 1971 Nov; 75(5):717-723. PubMed 4330677Contact Information
Core Lab Sendouts - Downtown: (315)464-6818